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3.1 Riboflavin transporter deficiency Riboflavin transporter deficiency (RTD)historically termed BrownVialettoVan Laere or Fazio-Londe syndromeis a rare, early-onset motor neuron disease that couples the biochemistry of riboflavin with overt neurodegeneration ( SLC52A2 or SLC52A3 abrogate membrane uptake of riboflavin, precipitating secondary FMN/FAD depletion in metabolically demanding neurons and glia ( Mechanistic work in patient fibroblasts and iPSC-derived motor neurons confirms that transporter mutations collapse intracellular FMN/FAD pools, impair respiratory-chain flux and trigger neurite loss
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Glutathione is a naturally occurring antioxidant found in every cell of the human body
Role of alcohol in the regulation of iron metabolism
Laxa M, Liebthal M, Telman W, Chibani K, Dietz KJ (2019) The role of the plant antioxidant system in drought tolerance
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